Giving nitrous oxide as part of general anesthesia for noncardiac surgery doesn’t increase the rate of complications and death – and might even decrease the risk of such events, according to a pair of studies in the May issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

But an accompanying series of editorials points out some important limitations of the two studies – which can’t completely overcome previous concerns about the safety of using nitrous oxide (N2O) as a surgical anesthetic.

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